Beverly Hills Spine Surgeon
Brian Perri, D.O.

Brian Perri, DO is an orthopedic spine surgeon who specializes in reconstructive surgery for spinal tumors and deformities as well as minimally invasive and motion preservation surgery for degenerative spinal diseases.

Dr. Perri received his bachelor’s degree from Allegheny College, his osteopathic medicine degree from Lake Erie College of Osteopathic Medicine, and his masters in neuroscience at the University of Hartford/University of Pennsylvania. Dr. Perri’s orthopedic residency was completed at Pinnacle Health Systems in Hershey, Pennsylvania. Dr. Perri also completed fellowship training in spine surgery at the Institute for Spinal Disorders/Spine Center at Cedars-Sinai Medical Center.

Dr. Perri’s research interests stemmed from his work on traumatic brain and spinal cord injury at the University of Pennsylvania. Dr. Perri has researched and performed surgeries with the newest technological advances in artificial disc replacement surgery in the lumbar and cervical spine, as well as developed a classification system for cervical kyphotic deformities with strategies and techniques for surgical reconstruction. In addition, Dr. Perri has advanced thoracoscopic sympathectomy surgery to a more minimally invasive procedure by using only two pinhole incisions under each arm. This surgery has a high success rate in completely resolving dysfunctional excessive sweating.

Dr. Perri has presented his findings at the Cedars-Sinai Symposium on Current Concepts in Spinal Disorders, Cervical Spine Research Society, North American Spine Society, Richard Lende Winter Neurosurgery Conference and the AANS/CNS Joint Section on Disorders of the Spine and Peripheral Nerves.

Dr. Perri has been a guest reviewer for The Spine Journal, the official journal of the North American Spine Society. Dr. Perri has also co-authored spine surgery textbook chapters on the complications and treatments of anterior cervical spine surgery, surgical treatment of acute cervical fractures, techniques for cervical-thoracic pedicle subtraction osteotomy for correction of cervical kyphosis, and thoracoscopic sympathectomy for treatment of hyperhidrosis.

Presently, Dr. Perri is a member of the American Ostoepathic Association, American Academy of Orthopedic Surgeons, North American Spine Society and International Society for the Advancement of Spine Surgery.

Publications

Education

Bachelors of Science in Biology, 1986-1990; Allegheny College, Meadville, PA
Masters in Neuroscience, 1990-1994; University of Hartford, West Hartford, CT/ University of Pennsylvania, Philadelphia, PA
Doctor of Osteopathy, 1995-1999; Lake Erie College of Osteopathic Medicine, Erie, PA
Orthopedic Surgery Resident, 1999-2005; Pinnacle Health Systems, Harrisburg, PA
Orthopedic Trauma - Pennsylvania State University, Hershey Medical Center, Hershey, PA
Pediatric Orthopedic Surgery - A.I. duPont Hospital for Children, Wilmington, DE
Spinal Surgery Fellowship, 2004-2005; Institute for Spinal Disorders Cedars-Sinai Medical Center, Los Angeles, CA
AOBOS Board Certified, 2008

Appointments

2005 to 2009; Associate Director, Orthopedic Spine Surgery Cedars-Sinai Institute for Spinal Disorders Los Angeles, California

2004 to Present; Attending Orthopedic Spine Surgeon Cedars-Sinai Medical Center Los Angeles, California

2012 to Present; Member of the Section on Spine Motion Technology North American Spine Society (NASS), Burr Ridge, IL

2013 to Present; Member of the International Society for the Advancement of Spine Surgery International Society for the Advancement of Spine Surgery (ISASS), Aurora, IL

Honors & Awards

1986-89; Allegheny College Soccer, Team Captain 1988 & 1989 seasons
1990-92; Regent’s Fellowship in Neuroscience, University of Hartford, West Hartford, CT
1994; 12th Annual Neurotrauma Symposium, Miami Beach, FL- Co-author of 1st Prize Poster Presentation Award for abstract titled: “Programmed Cell Death After Traumatic Brain Injury”
1997-98; Medical School Class President
2003; 1st Prize Research Presentation at Medical Education Day, Pinnacle Health, Harrisburg, PA-Award for abstract titled: “Recurrent Laryngeal Nerve Injury with Anterior Cervical Spine Surgery: Risk with Laterality of Surgical Approach”
2007; Award from Cedars-Sinai Medical Center O.R. for “Safety in the O.R.”

Research Interests

  • Reconstructive surgery for spinal tumors and deformities
  • Micro/minimal invasive surgery and motion preservation surgery for degenerative spinal diseases
  • Development of a classification system with subsequent strategies and techniques for the correction of cervical kyphotic deformities

Publications

1. Saatman, KE, Murai H, Bartus RT, Smith DH, Hayward NJ, Perri BR, McIntosh TK. “Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat.” Proc Natl Acad Sci USA 93(8):3428-33, Apr 1996.

2. McIntosh TK, Smith DH, Voddi M, Perri BR, Stutzmann JM. “Riluzole, a novel neuroprotective agent, attenuates both neurologic motor and cognitive dysfunction following experimental brain injury in the rat.” J Neurotrauma 13(12):767-80, Dec 1996.

3. Perri BR, Smith DH, Murai H, Sinson G, Saatman KE, Raghupathi R, Bartus RT, McIntosh TK. “Metabolic quantification of lesion volume following experimental traumatic brain injury in the rat.” J Neurotrauma 14(1):15-22, Jan 1997.

4. Sinson G, Perri BR, Trojanowski JQ, Flamm ES, McIntosh TK: “Neurotropin infusion improves cognitive deficits and decreased cholinergic neuronal cell loss and apoptotic cell death following experimental traumatic brain injury.” J Neurosurg. 86(3):511-8, Mar 1997.

5. Smith DH, Perri BR, Raghupathi R, Saatman, KE, McIntosh TK: “Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat.” Neurosci Lett. 231(3):135-8, Aug 15, 1997.

6. Perri BR, Lynch S: “Common Injuries in the Skilled Wrestler” (specific review includes pediatric cervical spine injuries). Current Opinion in Orthopedics 14:109-113, 2003.

7. Perri BR, Oyelese A, Bray RS, Johnson JP. “Classification of cervical kyphotic deformities: strategies and techniques for reconstruction surgery,” (submitted for publication).

8. Perri BR, Cooper M, Lauryssen C, Anand N: Adverse swelling associated with use of rhBMP-2 in anterior cervical discectomy and fusion: a case study. (submitted to The Spine Journal 2006).

9. Anand N, Hamilton JF, Perri BR, Miraliakbar H, Goldstein T: Cantilever TLIF with structural allograft and rhBMP-2 for correction and maintenance of segmental sagittal lordosis: clinical, radiographic and functional outcome. (submitted to Spine 2006).

10. Baron E, Siddique K, Perri B, Anand N, Johnson JP. Anterior transoral resection. Operative Techniques in Orthopedics. 17:156-162, Jul 2007.

11. Perri B, Siddique K, Baron E, Lauryssen C. Acute odontoid fractures: anterior odontoid fixation. Operative Techniques in Orthopedics. 17:163-168, Jul 2007.

12. Anand N, Baron EM, Siddique K, Perri B, Bray RS. Comparison of traditional midline approach versus muscle sparring paraspinal approach for posterior non-fusion stabilization of the lumbar spine-An analysis of functional outcomes. Journal of Neurosurgery Spine 2007.  Under review.

13. Mundwiler ML, Siddique K, Dym JM, Perri B, Johnson JP, Weisman MH. Complications of the spine in ankylosing spondylitis with a focus on deformity correction. Neurosurg Focus 24 (1): E6, 2008.

14. Ghostine S, Baron EM, Perri B, Jacobson P, Morsette D, Hsu FP. Thoracic cord herniation through a dural defect: description of a case and review of the literature. Surg Neurol. 2008 Jan 18 [Epub ahead of print].

15. Perri B, Ghostine S, Rapaport V, Johnson P, Siddique K: Treatment of Hyperhydrosis: Minimally Invasive Percutaneous Thoracoscopic Sympathectomy. Submitted to Arch Derm.  2008.

Chapters

1. Perri BR and Lauryssen C: “Complications in the IDE study using the Carbon Fiber Reinforced Polymer Cervical Cage for anterior cervical discectomy and fusion compared with those in clinical practice” in Intervertebral Fusion Using Carbon-Fiber Reinforced Polymer Implants—Principles, Implants, Techniques, and Case Examples. Edited by John W. Brantigan, MD. (in publishing)

2. Perri B, Siddique K, Anand N, Pashman R and Johnson JP. Charite SBIII Artificial Disc Replacement Techniques for Surgical Implantation. Instructional Video in Vaccaro, AR, Baron, EM Atlas of Spinal Surgery. Elsevier Medical Publishing, Philadelphia. 2007.

3. Mathur S, Perri B, Siddique K, Shanti N, Azer E. Acute Odontoid Fractures. In press, 2007.

4. Anand N, Perri BR: Posterior cervical osteotomy techniques. In: Vaccaro A, Baron Eli M. (eds) Operative Techniques in Spine Surgery (pp157-165), Elsevier, Philadelphia, PA, 2008.

5. Perri BR, Gravoori T, and Johnson JP. “Thoracoscopic Sympathetctomy” in Neurosurgical Operative Atlas 2E: Functional Neurosurgery (Chapter 25). Edited by Starr, Barbano and Larsen. Thieme Publishing (2008).

Textbooks

1. Perri, B. My Aching Back (Neck): What The So-called Experts Do for Theirs: A Multi-disciplinary Approach to caring for Your Spine. (in publishing)

Editorial Review Boards

1. Guest Reviewer, The Spine Journal, June 2005

Presentations

1. Perri BR, Beutler W: Recurrent Laryngeal Nerve Injury with Anterior Cervical Spine Surgery: Risk with Laterality of Surgical Approach”. North American Spine Society, Chicago, Illinois, October 30, 2004.

2. Perri BR, Oyelese T, Bray R, Johnson JP: Surgical correction of cervical kyphosis. Richard Lende Winter Neurosurgery Conference, Snowbird, Utah, Jan 29-31, 2005.

3. Perri BR, Miraliakbar H, Regan JJ, Johnson PJ, Bray R, Goldstein T, Lauryssen C: Complications of Charite Artificial Disc Replacement: Analysis of 86 (148) single-site consecutive cases from the prospective FDA IDE trial. American Association of Neurological Surgeons/Congress of Neurological Surgeons Joint Section on Disorders of the Spine and Peripheral Nerves, Phoenix, Arizona, Mar 2005.

4. Perri B. Session VII-Cervical TDR Clinical Data: Rationale, Controversies and Selection for Cervical ADR. Sixth Annual Symposium on Current Concepts in Spinal Disorders, Cedars-Sinai Institute for Spinal Disorders, Las Vegas, NV. March 2007.

5. Perri B. 2007 Clinical Symposia Series-Current Concepts in Spinal Disorders: Hyperhidrosis Update of Treatments and Complications. Los Angeles, CA. August 2008.

6. Perri B. Session VI-Complications & Problems in Routine Spinal Surgery: Post-Operative Infections-AN Update. Seventh Annual Symposium on Current Concepts in Spinal Disorders, Cedars-Sinai Institute for Spinal Disorders, Las Vegas, NV. Feb 2008.

7. Perri B. Session VII-Correction of Cervical Kyphotic Deformities. Eighth Annual Symposium on Current Concepts in Spinal Disorders, Cedars-Sinai Institute for Spinal Disorders, Las Vegas, NV. Jan 2009.

8. Perri B. Session IX-Avoiding Kyphotic Angulation in Cervical Arthroplasty. Ninth Annual Symposium on Current Concepts in Spinal Disorders, Cedars-Sinai Institute for Spinal Disorders, Las Vegas, NV. Feb 2010.

9. Perri B. Session VII-Motion Preservation: Multi-level Cervical Arthroplasty. Tenth Annual Symposium on Current Concepts in Spinal Disorders, Cedars-Sinai Institute for Spinal Disorders, Las Vegas, NV. Feb 2011.

10. Perri B. Current Minimal Invasive Surgical Decompression, Cedars-Sinai Medical Center Course, 2012.

Posters

1. Perri BR, Beutler W: Recurrent Laryngeal Nerve Injury with Anterior Cervical Spine Surgery: Risk with Laterality of Surgical Approach. Cervical Spine Research Society, Scottsdale, AZ, Dec 11-13, 2003.

2. “Strategies and Techniques for Correction of Cervical Kyphosis,” International Meeting for Advanced Spinal Technologies (IMAST), Banff, Alberta, Canada, July 2005.

3. Perri B, Oyelese A, Bray RS, Johnson JP: Strategies and techniques for correction of degenerative and post-surgical cervical kyphotic deformity. American Association of Neurological Surgeons (AANS)/CNS Section on Disorders of the Spine and Peripheral Nerves, Lake Buena Vista, FL, March 2006.

4. Perri B, Oyelese A, Bray RS, Johnson JP: Strategies and techniques for correction of degenerative and post-surgical cervical kyphotic deformity. American Association of Neurological Surgeons (AANS), San Francisco, CA, April 2006.

5. Anand N, Perri BR, Bray RS: Radiological analysis of segmental lumbar sagital alignment following posterior non-fusion stabilization with the Dynesys system. IMAST, Athens, Greece, July 2006.

6. Anand N, Perri BR, Bray RS: Hybrid combined fusion and non-fusion posterior stabilization of the lumbar spine with the Dynesys system: early clinical, radiological and functional outcomes. IMAST, Athens, Greece, July 2006.

Invited Speaker

1. Perri B, Oyelese A, Bray RS, Johnson JP: Strategies and techniques for correction of degenerative and post- surgical kyphotic deformity. AANS/CNS Section on Disorders of the Spine and Peripheral Nerves, Lake Buena Vista, FL, March 2006.

Intramural Lectures & Conferences

Strategies and management of cervical kyphosis. Cedars-Sinai Medical Center, Core Curriculum Lecture Series presented by the Institute for Spinal Disorders, Jan 12, 2005.

Merging technologies in lateral trans-psoas approach to the lumbar spine. Cedars-Sinai Medical Center, Institute for Spinal Disorders sponsored 4th Annual Symposium on Current Concepts in Spinal Disorders, Lake Las Vegas, Nevada, Feb 9-12, 2005.

Treatment options for degenerative lumbar scoliosis in 2005. Cedars-Sinai Medical Center, Core Curriculum Lecture Series presented by the Institute for Spinal Disorders, May 25, 2005.

Sports & Recreational Activities

Collegiate Soccer: Allegheny College, Team Captain, 1988-1989

Board Member: The Samburu Project.  This is a non-profit (501C3) organization to provide clean, safe drinking water to thousands among the Samburu Tribe outside of Kenya, Africa.

Brian Perri, DO – Publications

Treatment of Hyperhidrosis: Minimally Invasive Percutaneous Thoracoscopic Sympathectomy

Brian Perri, DO, Samer Ghostine, MD, Vicki Rapaport MD, Patrick Johnson, MD and Khawar Siddique, MD

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Acute Odontoid Fractures: Anterior Odontoid Fixation

Brian Perri, DO, Khawar Siddique, MD, Eli M. Baron, MD, and Carl Lauryssen, MD

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Common Injuries in the Skilled Wrestler

Brian R. Perri, DO and Scott A. Lynch, MD

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Metabolic Quantification of Lesion Volume following Experimental Traumatic Brian Injury in the Rat

Brian R. Perri, Douglas H. Smith, Hisayuki Murai, Grant Sinson, Kathryn E. Saatman, Ramesh Raghupathi, Raymond T. Bartus and Tracy K. McIntosh

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Ramacemide Hydrochloride reduces cortical lesion volume following brain trauma in the rat 

Douglas H. Smith, Brian R. Perri, Ramesh Raghupathi, Kathryn E. Saatman, Tracy K. McIntosh

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Posterior Cervical Osteotomy Techniques

Neel Anand and Brian Perri

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Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat
Kathryn E. Saatman, Hisayuki Murai, Raymond T. Bartus, Douglas H. Smith, Neil J. Hayward, Brian R. Perri and Tracy K. McIntosh

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Improvement of cognitive deficits and decreased cholinergic neuronal cell loss and apoptotic cell death following neurotophin infusion after experimental traumatic brain injury

Grant Sinson, MD, Brian R. Perri, B.A., John Q. Trojanowski, MD, PhD, Eugene S. Flamm, MD, and Tracy K. McIntosh, PhD.

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Riluzole, a Noval Neuroprotective Agent, Attenuates Both Neurologic Motor and Cognitive Dysfunction Following Experimental Brain Injury in the Rat

Tracy K McIntosh, Douglas H. Smith, Madhu Voddi, Brian R. Perri, and Jean-Marie Stutzmann

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Chapter 25 Thoracoscopic Sympathectomy

Brian Perri, DO, Tooraj Gravori MD, J. Patrick Johnson MD

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